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Dr. Chhavi GuptaBlogYashodaHospital
TB admin

ATT-Induced Liver Dysfunction: A Serious Concern in TB Management

Understanding ATT and Its Role

Anti-tuberculosis therapy (ATT) is the standard treatment for tuberculosis, typically involving a combination of drugs like isoniazid, rifampicin, pyrazinamide, and ethambutol. While these drugs are effective, some of them carry a known risk of liver toxicity.

What Is ATT-Induced Liver Dysfunction?

ATT-induced liver dysfunction refers to liver damage that occurs as a side effect of TB medications. It often presents as elevated liver enzymes (transaminases), and in some cases, may progress to jaundice or even acute liver failure if left unmonitored.

Symptoms to Watch For

  • Nausea and vomiting
  • Abdominal pain (especially in the right upper quadrant)
  • Jaundice (yellowing of eyes and skin)
  • Fatigue or general weakness
  • Dark-colored urine

Who Is at Risk?

Patients at higher risk for liver toxicity from ATT include:

  • Those with pre-existing liver disease (e.g., hepatitis B or C)
  • People with poor nutritional status
  • Elderly individuals
  • Those who consume alcohol regularly
  • HIV-positive individuals
  • Monitoring and Management
  • Baseline Liver Function Tests (LFTs) should be done before starting ATT
  • Routine monitoring is important, especially during the first two months
  • If significant liver injury occurs, drugs may need to be paused and reintroduced gradually under expert guidance
  • Modified regimens or hepatoprotective agents may be considered

Why Early Detection Matters

Delays in recognizing liver dysfunction can lead to serious complications and jeopardize TB treatment. Timely action can prevent permanent damage and allow patients to safely complete their course of therapy.

If you or someone you know is undergoing TB treatment and experiencing symptoms of liver dysfunction, consult an infectious disease specialist immediately.

Dr. Chhavi Gupta
MBBS, MD, DM (AIIMS, New Delhi)
Senior Consultant – Infectious Diseases
Yashoda Super Speciality Hospital, Kaushambi
📞 For Appointments: +91 8851 346 424
🌐 drchhavigupta.com

Vaccine admin

Understanding Rabies: Prevention, Symptoms, and Treatment

Rabies is a deadly viral disease that affects the central nervous system of mammals, including humans. Transmitted primarily through the bite or scratch of an infected animal, rabies is almost always fatal once symptoms appear. However, it is completely preventable through vaccination and proper wound care.

What is Rabies?

Rabies is caused by the rabies virus, which spreads through the saliva of infected animals, commonly dogs, bats, raccoons, and foxes. Once the virus enters the body, it travels to the brain, causing inflammation that leads to severe neurological symptoms and, ultimately, death.

Symptoms of Rabies

Rabies symptoms typically appear within 1 to 3 months after exposure but can vary from a few days to several years. Early symptoms may resemble the flu, including fever, headache, and fatigue. As the disease progresses, more severe symptoms develop, such as:

  • Anxiety and confusion
  • Excessive salivation
  • Difficulty swallowing
  • Hydrophobia (fear of water)
  • Paralysis
  • Hallucinations and aggression
  • Once symptoms appear, rabies is almost always fatal, making early intervention crucial.

Prevention of Rabies

  1. Vaccination: Rabies vaccination is the most effective way to prevent the disease. This includes:
    • Pre-exposure vaccination for people at high risk, such as veterinarians and travelers to high-risk areas.
    • Post-exposure prophylaxis (PEP) for anyone bitten or scratched by a potentially rabid animal.
  2. Animal Control and Vaccination: Ensure pets are vaccinated against rabies and avoid contact with wild animals.
  3. Immediate Wound Care: If bitten, wash the wound thoroughly with soap and water and seek medical attention immediately.

Treatment for Rabies

  • If exposed to rabies, immediate medical care is essential. Post-exposure prophylaxis (PEP) involves:
  • Rabies Immune Globulin (RIG) for immediate antibodies.
  • Rabies Vaccine Series to stimulate the body’s immune response.

Consult an Expert Today

  • Dr. Chhavi Gupta, MBBS, MD, DM (AIIMS, New Delhi)
    Senior Consultant, Infectious Diseases
    Yashoda Super Speciality Hospital, Kaushambi

    📞 +91 8851 346 424
    🌐 drchhavigupta.com

Fever admin

Understanding Sepsis: Causes, Symptoms, and Prevention

Sepsis is a life-threatening condition that arises when the body’s response to infection causes widespread inflammation, leading to tissue damage, organ failure, and potentially death. While often triggered by bacterial infections, sepsis can result from any type of infection, including viral, fungal, or parasitic. Early recognition and prompt treatment are crucial in preventing serious outcomes.

What Is Sepsis?
Sepsis occurs when the body’s immune system, which normally helps fight infections, goes into overdrive. Instead of targeting just the infection, the immune system begins to attack the body’s own tissues and organs. This widespread inflammation can lead to dangerous drops in blood pressure, shock, and multi-organ failure if left untreated.

Common Causes of Sepsis
Sepsis can develop from various infections, including:

  • Pneumonia (lung infection)
  • Urinary Tract Infections (UTIs)
  • Abdominal Infections (e.g., appendicitis or peritonitis)
  • Skin Infections (e.g., cellulitis)
  • Surgical Wound Infections

While anyone can develop sepsis, certain groups are more vulnerable:

  • The elderly
  • People with weakened immune systems
  • Patients with chronic conditions (e.g., diabetes, kidney disease)
  • Infants and young children
  • People with recent surgeries or invasive medical procedures

Recognizing the Symptoms of Sepsis
The early symptoms of sepsis can mimic other less severe illnesses, which makes it difficult to identify. However, the following signs should not be ignored:

  • High fever or chills
  • Rapid breathing and heart rate
  • Confusion or disorientation
  • Extreme pain or discomfort
  • Clammy, sweaty skin
  • Decreased urine output
  • Low blood pressure (a sign of septic shock)

If you or someone you know shows these symptoms after an infection, it is critical to seek medical attention immediately. Sepsis is a medical emergency, and early intervention can save lives.

How is Sepsis Diagnosed?
Healthcare providers diagnose sepsis based on a combination of symptoms, blood tests, and imaging studies. Blood tests can help identify the infection source and measure inflammation levels, while imaging such as X-rays or CT scans may pinpoint the location of an infection.

Treatment of Sepsis
Once diagnosed, the main goals of sepsis treatment are to:

  1. Control the infection – Antibiotics or antivirals are administered as soon as possible.
  2. Support vital organ function – This may involve intravenous fluids, oxygen, or medications to stabilize blood pressure.
  3. Remove the infection source – In some cases, surgery may be required to drain abscesses or remove infected tissue.

Timely and aggressive treatment is key to improving outcomes for patients with sepsis. Intensive care support may be needed for patients in severe stages.

Preventing Sepsis
Since sepsis is often triggered by infections, preventing infections is the first step in reducing the risk of sepsis. Some effective preventive measures include:

  • Vaccination: Ensure you are up to date on vaccines, especially those that protect against pneumonia, influenza, and other infections.
  • Hygiene: Regular hand washing, especially after using the restroom or before handling food, can prevent the spread of infections.
  • Proper Wound Care: Clean and cover cuts, scrapes, and other wounds to prevent infection.
  • Seek Prompt Medical Care: If you suspect an infection, especially after surgery or a medical procedure, seek medical help early before complications arise.

The Importance of Early Recognition
Sepsis can progress rapidly. What starts as a mild infection may evolve into septic shock within hours, which is why early recognition is vital. Health campaigns focus on raising awareness of sepsis symptoms so patients and caregivers can act quickly and prevent long-term damage or death.

Conclusion
Sepsis is a critical condition, but it is preventable and treatable when recognized early. Awareness of the symptoms and risk factors can help reduce the risk of developing sepsis or experiencing complications. If you or someone you know is experiencing signs of sepsis after an infection, seek medical attention immediately.

For expert care in managing infections and preventing complications like sepsis, consult with Dr. Chhavi Gupta, an Infectious Diseases Specialist with vast experience in diagnosing and treating infections.

📞 Book an appointment: +91 8851 346 424 | 🌐 Visit: drchhavigupta.com

Fever admin

Understanding Monkeypox: Causes, Symptoms, and Prevention

Monkeypox is an emerging viral disease that has gained attention due to its ability to affect humans, primarily in areas of Africa, but has recently spread to other regions as well. The virus that causes monkeypox belongs to the same family as the smallpox virus, although monkeypox is generally less severe. However, with its increasing spread, it is crucial to be informed about its causes, symptoms, and ways to prevent infection.

What is Monkeypox?

Monkeypox is a zoonotic virus, meaning it can be transmitted from animals to humans. It was first identified in 1958 in monkeys kept for research, which is how it got its name, though the primary carriers are thought to be rodents. The first human case was recorded in 1970 in the Democratic Republic of Congo.

How Does Monkeypox Spread?

Monkeypox can spread through close contact with an infected animal or person. Human-to-human transmission occurs via respiratory droplets, contact with bodily fluids, or direct contact with the skin lesions of an infected person. The virus can also be spread through contaminated objects such as bedding or clothing.

Sexual transmission has also been recognized as an important route for the spread of monkeypox, further highlighting the importance of awareness and preventive measures.

Symptoms of Monkeypox

The incubation period for monkeypox ranges from 5 to 21 days. Initial symptoms are similar to other viral infections, making early diagnosis challenging. These symptoms include:

  • Fever
  • Chills
  • Headache
  • Muscle and back aches
  • Exhaustion
  • Swollen lymph nodes

A key symptom that distinguishes monkeypox from other viral infections is the development of a rash. The rash typically begins on the face and then spreads to other parts of the body. It starts as flat red spots, which then turn into blisters filled with pus. These blisters eventually crust over and fall off. The rashes are often painful and itchy, causing significant discomfort.

Is Monkeypox Life-Threatening?

Monkeypox is often self-limiting, meaning symptoms usually go away within two to three weeks. However, in some cases, it can lead to complications, especially in individuals with weakened immune systems, children, or those with pre-existing health conditions. Complications can include secondary infections, pneumonia, and in rare cases, death.

Prevention and Treatment

There is no specific treatment for monkeypox, but supportive care and treatment of symptoms can help. Smallpox vaccines have been shown to be about 85% effective in preventing monkeypox and may be recommended for people at high risk of exposure.

Preventive measures include:

Avoiding contact with animals that could harbor the virus, especially in areas where monkeypox is endemic.
Practicing good hand hygiene, particularly after contact with animals or sick individuals.
Isolating infected patients to prevent the spread of the virus.
Using personal protective equipment (PPE) when caring for infected individuals.
Conclusion

While monkeypox is not as widespread or as severe as many other viral infections, its potential to cause outbreaks makes it a public health concern. Being informed about the symptoms, modes of transmission, and preventive measures is key to controlling its spread.

If you suspect exposure to monkeypox or are experiencing symptoms, it is crucial to seek medical advice. For expert guidance and treatment, consult Dr. Chhavi Gupta, an Infectious Diseases Specialist from AIIMS, New Delhi, now available at Yashoda Super Speciality Hospital, Delhi NCR.

Contact for Appointment: 8851 346 424